SIMAI 2025

IS022 - Mechanobiology of Cell Migration: Insights from Mathematical Modelling

Organized by: F. Ballatore (Politecnico di Torino, Italy) and D. Morselli (University College London, United Kingdom)
Keywords: Computational biomedicine, mathematical biology, mechanics, Scientific computing
Cell migration in confined environments is a fundamental mechanobiological process that plays a crucial role in contexts such as development and embryogenesis, immune response, and cancer metastasis. This phenomenon often involves an epithelial-to-mesenchymal transition, which endows cells with migratory and invasive capabilities. Additionally, the nucleus may play a critical role in confining extracellular matrix environments since it may gradually slow down and even inhibit migration. Cell movement is governed by a complex interplay of biochemical and biomechanical cues, including fibre contact guidance, chemotactic signals, and stochastic fluctuations. While it is known that these stimuli can either compete or cooperate, the exact cellular response to multiple cues remains poorly understood. Recent advances in experimental and imaging techniques have provided valuable insights into cellular deformations under specific mechanical constraints. At the same time, new methods enable a detailed characterisation of extracellular matrix alignment and chemoattractant distribution, which could, in principle, help elucidate cell movement. However, fully quantifying stress and strain fields, as well as the parameters governing cellular responses to different stimuli, remains a challenge. Mathematical modelling serves as a powerful tool to investigate these processes, particularly when experimental data are scarce or difficult to obtain. Moreover, computational approaches are crucial for validating theoretical predictions against empirical observations, ultimately offering new perspectives on cell dynamics. This mini-symposium aims to provide an overview of the latest research on cell migration models, encompassing both analytical approaches and numerical simulations. We seek to foster discussions by bringing together a diverse and gender-balanced group of researchers from different institutions.